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Brundin L, Björkqvist M, Träskman-Bendz L and Petersén Å.Psychiatry Research 158(2): 117-122 (2008)AbstractCocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed in brain regions thought to regulate anxiety levels, depression, addiction and energy homeostasis. Individuals with a CART mutation display increased anxiety and depression. Severe anxiety is a core phenomenon of

https://www.huntington-research.lu.se/cocaine-and-amphetamine-regulated-transcript-cart-cohort-suicide-attempters - 2026-06-03

Fjalldal S, Follin C, Gabery S, Sundgren PC, Björkman-Burtscher IM, Lätt J, Mannfolk P, Nordström CH, Rylander L, Ekman B, Cheong R, Pålsson A, Petersén Å and Erfurth EM.International Journal of Obesity (Lond). 43: 533-544 (2019) AbstractBACKGROUND/OBJECTIVES:Hypothalamic obesity (HO) occurs in 50% of patients with the pituitary tumor craniopharyngioma (CP). Attempts have been made to predict the

https://www.huntington-research.lu.se/detailed-assessment-hypothalamic-damage-craniopharyngioma-patients-obesity - 2026-06-03

Wood N, Goodman AOG, van der Burg J, Gazeau V, Brundin P, Björkqvist M, Petersén Å, Tabrizi SJ, Barker RA and Morton AJ.Brain Research Bulletin 76: 70-79 (2008)AbstractWhile Huntington's disease (HD) is a condition that primarily involves the basal ganglia, there is evidence to suggest that the hypothalamus is also affected. Because the osmoreceptors regulating thirst are situated in the circumven

https://www.huntington-research.lu.se/increased-thirst-and-drinking-huntingtons-disease-and-r62-mouse - 2026-06-03

Schultz K, Träskman-Bendz L and Petersén Å.Journal of Affective Disorders 109: 205-208 (2008)AbstractBACKGROUND: Earlier studies have found that transthyretin (TTR) is reduced in cerebrospinal fluid (CSF) from patients with major depressive disorder and that levels correlate negatively with suicidal ideation. The purpose of this study was to examine CSF-TTR in a cohort of suicide attempters with d

https://www.huntington-research.lu.se/transthyretin-cerebrospinal-fluid-suicide-attempters - 2026-06-03

Araújo IM, Gil J, Carreira BP, Mohapel P, Petersén Å, Pinheiro PS, Soulet D, Bahr BA, Brundin P and Carvalho CM.Journal of Neurochemistry 105: 666-676 (2008)AbstractEvidence for increased calpain activity has been described in the hippocampus of rodent models of temporal lobe epilepsy. However, it is not known whether calpains are involved in the cell death that accompanies seizures. In this work,

https://www.huntington-research.lu.se/calpain-activation-involved-early-caspase-independent-neurodegeneration-hippocampus-following-status - 2026-06-03

van der Burg JMM, Bacos K, Wood N, Lindqvist A, Wierup N, Wamsteeker J, Deierborg-Olsson T, Mulder H, Erlanson-Albertsson C, Morton J, Brundin P, Björkqvist M* and Petersén Å*.Neurobiology of Disease 29: 41-51 (2008) *equal contribution AbstractHuntington's disease (HD) is a hereditary disorder characterized by personality changes, chorea, dementia and weight loss. The cause of this weight loss is

https://www.huntington-research.lu.se/increased-metabolism-r62-mouse-model-huntingtons-disease - 2026-06-03

Dalrymple A, Wild E, Joubert R, Sathasivam K, Björkqvist M, Petersén Å, Isaacs J, Kristiansten M, Bates G, Leavitt B, Keir G, Ward M and Tabrizi SJ.Journal of Proteome Research 6: 2833-2840 (2007)AbstractHuntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatm

https://www.huntington-research.lu.se/proteomic-profiling-plasma-hungtintons-disease-reveals-neuroinflammatory-acivation-and-biomarker - 2026-06-03

Brundin L, Petersén Å, Björkqvist M and Träskman-Bendz L.Journal of Affective Disorders 100: 259-263 (2007)AbstractBACKGROUND:The orexins (hypocretins) are recently discovered hypothalamic peptides that are involved in the regulation of sleep, appetite and state of arousal. In the present study, we investigated the relationship between cerebrospinal fluid (CSF) orexin and specific psychiatric symp

https://www.huntington-research.lu.se/orexin-and-psychiatric-symptoms-suicide-attempters - 2026-06-03

Björkqvist M, Leavitt B, Nielsen J, Landwehrmeyer B, Ecker D, Mulder H, Brundin P and Petersén Å.Movement Disorders 22: 1952-1954 (2007)AbstractWeight loss and anxiety frequently occur in individuals with Huntington's disease (HD) but the underlying mechanisms are not well-understood. Peptides produced in the hypothalamus are involved in regulating energy homeostasis and emotion. Recent data sugge

https://www.huntington-research.lu.se/cocaine-and-amphetamine-regulated-transcript-increased-huntington-disease - 2026-06-03

Brundin L, Björkqvist M, Petersén Å and Träskman-Bendz L.European Neuropsychopharmacology 17: 573-579 (2007)AbstractOrexins are neuropeptides selectively expressed in a small number of neurons in the lateral-posterior hypothalamus. We measured orexin-A in the cerebrospinal fluid (CSF) of 66 patients with major depressive disorder (MDD), dysthymia and adjustment disorder after a suicide attempt. Bl

https://www.huntington-research.lu.se/reduced-orexin-levels-cerebrospinal-fluid-suicidal-patients-major-depressive-disorder - 2026-06-03

Van Raamsdonk JM, Murphy Z, Selva DM, Hamidizadeh R, Pearson J, Petersen Å, Björkqvist M, Muir C, Mackenzie IR, Hammond GL, Vogl AW, Hayden MR and Leavitt BR.Neurobiology of Disease 26: 512-520 (2007)AbstractHuntington disease (HD) is an adult onset, neurodegenerative disorder that results from CAG expansion in the HD gene. Recent work has demonstrated testicular degeneration in mouse models of HD

https://www.huntington-research.lu.se/testicular-degeneration-huntington-disease - 2026-06-03

Petersén Å and Björkqvist M.European Journal of Neuroscience 24: 961-967 (2006)AbstractHuntington's disease (HD) is a hereditary and fatal disorder caused by an expanded CAG triplet repeat in the HD gene, resulting in a mutant form of the protein huntingtin. Wild-type and mutant huntingtin are expressed in most tissues of the body but the normal function of huntingtin is not fully known. In HD, th

https://www.huntington-research.lu.se/hypothalamic-endocrine-aspects-huntingtons-disease - 2026-06-03

Baldo B, Sajjad MU, Cheong RY, Bigarreau J, Vijayvargia R, McLean C, Perrier AL, Seong IS, Halliday G, Petersén Å and Kirik D.ENeuro 5 (4). pii: ENEURO.0234-18.2018 (2018)AbstractThe neurodegenerative Huntington's disease (HD) is caused by a polyglutamine (polyQ) amplification in the huntingtin protein (HTT). Currently there is no effective therapy available for HD; however, several efforts are di

https://www.huntington-research.lu.se/quantification-total-and-mutant-huntingtin-protein-levels-biospecimens-using-novel-alphalisa-assay - 2026-06-03

Björkqvist M*, Petersén Å*, Nielsen J, Ecker D, Mulder H, Hayden M, Landwehrmeyer B, Brundin P and Leavitt B.Clinical Genetics 70: 78-79 (2006) *equal contribution Full text article    

https://www.huntington-research.lu.se/cerebrospinal-fluid-levels-orexin-levels-are-not-useful-biomarker-huntington-disease - 2026-06-03

Björkqvist M, Petersén Å, Bacos K, Isaacs J, Norlén P, Gil J, Popovic N, Sundler F, Bates GP, Tabrizi SJ, Brundin P and Mulder H.Human Molecular Genetics 15: 1713-1721 (2006)AbstractHuntington's disease (HD) is characterized by a triad of motor, psychiatric and cognitive symptoms. Although many of these symptoms are likely to be related to central nervous system pathology, others may be due to cha

https://www.huntington-research.lu.se/progressive-alterations-hypothalamic-pituitary-adrenal-axis-r62-transgenic-mouse-model-huntingtons - 2026-06-03

Winkler C, Gil JMAC, Araújo IM, Rieß O, Skripuletz I, von Hörsten S and Petersén Å.Brain Research Bulletin 69: 306-310 (2006)AbstractHuntington's disease (HD) is a hereditary neurodegenerative disorder caused by a CAG repeat expansion in the HD gene. Excitotoxic cell damage by excessive stimulation of glutamate receptors has been hypothesized to contribute to the pathogenesis of HD. Transgenic mou

https://www.huntington-research.lu.se/normal-sensitivity-excitotoxicity-transgenic-huntingtons-disease-rat - 2026-06-03

Gawlik KI, Li J-Y, Petersén Å and M Durbeej.Human Molecular Genetics 15: 2690-2700 (2006)AbstractAbsence of laminin alpha2 chain leads to a severe form of congenital muscular dystrophy (MDC1A) associated with peripheral neuropathy. Hence, future therapies should be aimed at alleviating both muscle and neurological dysfunctions. Pre-clinical studies in animal models have mainly focused on ameliorat

https://www.huntington-research.lu.se/laminin-alpha1-chain-improves-laminin-alpha2-chain-deficient-peripheral-neuropathy - 2026-06-03

Petersén Å, Gil J, Maat-Schieman MLC, Björkqvist M, Tanila H, Araujo IM, Smith R, Popovic N, Wierup N, Norlén P, Li JY, Roos RAC, Sundler F, Mulder H and Brundin P.Human Molecular Genetics 14: 39-47 (2005).AbstractHuntington's disease (HD) is a devastating neurodegenerative disorder caused by an expanded CAG repeat in the gene encoding huntingtin, a protein of unknown function. Mutant huntingtin f

https://www.huntington-research.lu.se/orexin-loss-huntingtons-disease - 2026-06-03

Puschban Z, Stefanova N, Petersén Å, Winkler C, Brundin P, Poewe IW and Wenning GP.Brain Research Bulletin 68: 54-58 (2005)AbstractEmbryonic transplantation has been considered as an alternative treatment strategy for drug resistant parkinsonian symptoms in multiple system atrophy. So far our group has created a number of animal models of striatonigral degeneration, the core pathology underlying p

https://www.huntington-research.lu.se/evidence-dopaminergic-re-innervation-embryonic-allografts-optimized-rat-model-parkinsonian-variant - 2026-06-03

Gil JM, Mohapel P, Araujo IM, Popovic N, Li JY, Brundin P and Petersen Å.Neurobiology of Disease 3: 744-751 (2005)AbstractWe investigated whether cell proliferation and neurogenesis are altered in R6/2 transgenic Huntington's disease mice. Using bromodeoxyuridine (BrdU), we found a progressive decrease in the number of proliferating cells in the dentate gyrus of R6/2 mice. This reduction was detec

https://www.huntington-research.lu.se/reduced-hippocampal-neurogenesis-r62-transgenic-huntingtons-disease-mice - 2026-06-03